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Diss Factsheets
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EC number: 241-555-0 | CAS number: 17586-94-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro Gene Mutation Study in Bacteria
The key study, Krul (2010) was submitted to fulfil the data requirement for in vitro mutagenicity in bacteria. The study was performed in accordance with standardised guidelines, OECD 471 and EPA OPPTS 870.5100 and in accordance with GLP. The study was both performed and reported to a high standard. As such it was deemed acceptable to assign the study a reliability score of 1 in accordance with the criteria for assessing data quality as outlined in Klimisch (1997). Under the conditions of the test, the test substance did not induce an increase in revertants in the bacterial strains selected for the study.
In vitro Gene Mutation
The key study, Flanders (2012), was performed in accordance with standardised guidelines OECD 476, EU Method B.17 and EPA OPPTS 870.5300 and in line with GLP. The study was both performed and reported to a high standard. As such it was deemed acceptable to assign the study a reliability score of 1 in accordance with the criteria for assessing data quality as outlined in Klimisch (1997). Under the conditions of the assay, the test material was determined not to be mutagenic in L5178Y TK+/- cells treated in vitro in either the presence or absence of metabolic activation.
In vivo Cytogenicity Test:
The key study, de Vogel (2004), was performed in accordance with the standardised guideline OECD 474 and in line with GLP. The study was reported to a high standard and was sufficient to assess the genotoxic and clastogenic potential of the substance. In accordance with the criteria for assessing data quality as outlined in Klimisch (1997), the study was assigned a reliability score of 1. The test substance was found not to induce chromosome damage, or damage to the mitotic spindle apparatus under the conditions of the test, and was concluded to be negative for genotoxicity and clastogenicity.
Justification for selection of genetic toxicity endpoint
As multiple studies are presented to address genetic toxicity, no one study was selected as the key study as they represent different types of genetic toxicity and are therefore not comparable.
Short description of key information:
In vitro Gene Mutation Study in Bacteria
Key study:- Krul (2010), OECD 471 and EPA OPPTS 870.5100; Negative up to precipitating concentrations.
In vitro Gene Mutation
Key study:- Flanders (2012), OECD 476, EU Method B.17, EPA OPPTS 870.5300; Negative up to precipitating concentrations
In vivo Cytogenicity Test
Key study:- de Vogel (2004), OECD 474; Negative up to 2000 mg/kg bw (limit concentration)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
In accordance with with criteria for classification and labelling as defined in Regulation (EC) No 1272/2008 (CLP) and Directive 67/548/EEC (DSD), the test material does not require classification for genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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