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EC number: 231-415-7
CAS number: 7540-51-4
Skin sensitising potential of the test substance was assessed on the
source substance DL-Citronellol by an activation of keratinocytes study
and an LLNA study.
The activation of keratinocytes study concluded that the substance shows
no indication of being a skin sensitiser.
Skin sensitisation was assessed in an LLNA (OECD 429) where
approximately 25µl of a 2.5, 5, 10, 25 or 50% w/v preparation of the
test substance in 1:3 Et0H:DEP was applied to the dorsal surface of each
ear for 3 consecutive days. The EC3 value was calculated to be 43.5% w/v
(1 0875µg/cm²). Therefore, the substance is classified as Skin
A skin sensitiser is defined as a substance that will lead to an
allergic response following skin contact.
Substances are classified as skin sensitisers (Category 1) if there is
evidence in humans that the substance can lead to sensitisation by skin
contact in a substantial number of persons, or if there are positive
results from an appropriate animal test.
Substances may also be classified into:
sub-category 1A: substances showing a high frequency of occurrence in
humans and/or a high potency in animals can be presumed to have the
potential to produce significant sensitisation in humans) or sub-category
1B: substances showing a low to moderate frequency of occurrence in
humans and/or a low to moderate potency in animals can be presumed to
have the potential to produce sensitisation in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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