Registration Dossier
Registration Dossier
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EC number: 208-706-2 | CAS number: 538-93-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset - Substance ID: 538–93–2
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Remarks:
- documentation insufficient for assessment
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutylbenzene
- EC Number:
- 208-706-2
- EC Name:
- Isobutylbenzene
- Cas Number:
- 538-93-2
- Molecular formula:
- C10H14
- IUPAC Name:
- (2-methylpropyl)benzene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume): 2.34 ml/kg
- single treatment
- Duration of exposure:
- no data available
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- no further data available
- Statistics:
- no data available
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no effects observed
- Clinical signs:
- - no clinical signs of systemic reaction
- slight or well defined erythema at the sites of application by day 2 (resolved by day 3 in male rats and day 4 in females) - Body weight:
- no data available
- Gross pathology:
- no effects observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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