Registration Dossier
Registration Dossier
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EC number: 204-527-9 | CAS number: 122-19-0
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 31, 2018 to January 31, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- air comparison pycnometer (for solids)
- Key result
- Type:
- relative density
- Density:
- ca. 1.016 other: Dimensionless
- Temp.:
- 20 °C
- Conclusions:
- Under the study conditions, the relative density of the test substance is determined to be 1.0156 at 20 ± 0.1˚C.
- Executive summary:
A study was conducted to determine the relative density of the test substance, C18 ADBAC (active: 96.2%), using air comparison pycnometer method, according to OECD Guideline 109 and EU Method A.3, in compliance with GLP. Under the study conditions, the relative density of the test substance is determined to be 1.0156 at 20 ± 0.1˚C (Kremer, 2018).
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 24, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- buoyancy method - hydrostatic balance
- Key result
- Type:
- relative density
- Density:
- ca. 0.981 other: Dimensionless
- Temp.:
- 20.38 °C
- Conclusions:
- Under study conditions, the relative density of the test substance was determined to be 0.981.
- Executive summary:
A study was conducted to determine the relative density of the test substance, C18 ADBAC (active: 89.5%), using hydrostatic balance method, according to the OECD Guideline 109, in compliance with GLP. Under study conditions, the relative density of the test substance was determined to be 0.981 at 20.38˚C (Scymaris, 2017).
Referenceopen allclose all
Results of the measurements of density of test substance:
| Test no | Temperature (C) | Amount of test substance (g) | Average sample volume (cm3) | Density (g/cm3) |
| 1 | 20 | 8.52 | 8.38733 | 1.01582 |
| 2 | 20 | 8.61 | 8.47931 | 1.01541 |
Density test results
Test Substance Number |
Test Temperature (°C) |
Density of water at test temperature (g/cm3) |
Weight of substance in air (g) |
Buoyancy (G) |
Relative Density (g/cm3) |
Mean Relative Density (g/cm3) |
Standard Deviation |
Relative Standard Deviation (%) |
1014.005 |
20.1 |
0.99821 |
0.13160 |
0.13320 |
0.98759 |
0.98138 |
0.00709 |
0.72 |
1014.005 |
20.4 |
0.99815 |
0.27485 |
0.28216 |
0.97366 |
|||
1014.005 |
20.4 |
0.99815 |
0.13178 |
0.13401 |
0.98291 |
|||
1014.005 |
20.5 |
0.99813 |
0.10409 |
Outlier |
||||
1014.005 |
20.5 |
0.99813 |
0.18232 |
Outlier |
Description of key information
The relative density of the test substance was determined using the air comparison pycnometer method, according to OECD Guideline 109 and EU Method A.3 (Kremer, 2018) and the hydrostatic balance method, according to OECD Guideline109 (Scymaris, 2017).
Key value for chemical safety assessment
- Relative density at 20C:
- 0.981
Additional information
Two studies were available with the test substance:
- Study 1: 1.0156 at 20 ± 0.1˚C (Kremer, 2018).
Study 2: 0.981 at 20.38˚C (Scymaris, 2017).
As a conservative approach, the slightly lower density value has been considered further for hazard assessment. This is because for low soluble substances, the relative density parameter is used to assess if the substance will float or sink in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
