Reaction mass of methyl 2-methylbenzene-1-sulfonate and methyl toluene-4-sulphonate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1960

Report date:

1960

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The skin irritation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 404), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

methyl 2-methylbenzene-1-sulfonate

Cas Number:

23373-38-8

Molecular formula:

C8H10O3S

IUPAC Name:

methyl 2-methylbenzene-1-sulfonate

Constituent 2

Reference substance name:

Methyl toluene-4-sulphonate

EC Number:

201-283-5

EC Name:

Methyl toluene-4-sulphonate

Cas Number:

80-48-8

Molecular formula:

C8H10O3S

IUPAC Name:

methyl 4-methylbenzene-1-sulfonate

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

no information available

Test system

Type of coverage:

open

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

yes, concurrent no treatment

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data available

Duration of treatment / exposure:

1 min., 5 min., 15 min. and 20 hour(s)

Observation period:

14 days

Number of animals:

no data available

Details on study design:

The backs and ears of very susceptible white rabbits were treated with undiluted test material. After several exposure times the application side was examined after washing (after 1, 5 and 15 minutes exposure; no washing after exposure during 20 hours). The effects observed were described qualitatively.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol concentrated and afterwards with Lutrol diluted to 50 % with water.


- Scoring system: no data, results are described qualitatively
- Examination time points: at the end of exposure

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: qualitative description of effects

Basis:

animal:

Time point:

other: after 1, 5 and 15 minutes

Remarks on result:

no indication of irritation

Results 2

Irritation parameter:

other: qualitative description of effects

Basis:

animal:

Time point:

other: 20 hours and 14 days after the end of exposure

Reversibility:

other: fully reversible within 14 days.

Remarks on result:

other: inflammation followed by degeneration involving only the upper layers of the skin

Applicant's summary and conclusion

Interpretation of results:

other: irritant

Executive summary:

In a study already performed in the 1960s the undiluted test substance was severely irritant to the rabbit´s skin after a 20-hours contact period, as evidenced by skin inflammation with scabs and scales formation which were reversible at the end of the 14-days observation period.