Registration Dossier
Registration Dossier
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EC number: 210-288-1 | CAS number: 611-99-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Details not given in the document
- Deviations:
- not specified
- Principles of method if other than guideline:
- The Benzophenones have been tested for acute oral toxicity in rats. The animals were weighed and dosed after a one-week observation;
- GLP compliance:
- not specified
- Remarks:
- This in-vivo research was carried out in 1983, prior to GLP requirements
- Test type:
- other: not specified but likely to be standard acute method
Test material
- Reference substance name:
- 2,4-dihydroxybenzophenone
- EC Number:
- 205-029-4
- EC Name:
- 2,4-dihydroxybenzophenone
- Cas Number:
- 131-56-6
- Molecular formula:
- C13H10O3
- IUPAC Name:
- 2,4-dihydroxybenzophenone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals were weighed and dosed after a one-week observation; the test material was then administered by gastric intubation. Rats were observed daily for 7 to 14 days, during which time food and water were allowed ad libitum; in some instances, animals were sacrificed and autopsied for gross pathology.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The substance was diluted with corn oil to a 25% solution.
- Doses:
- 8 - 32 ml/kg
- No. of animals per sex per dose:
- 50
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 24.4 mL/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the 2,4-dihydroxybenzophenone, which is assessed as an acceptable surrogate for 4,4-dihydroxybenzophenone was reported to be 24.4 ml/kg in a study of 50 rats. The solution administered was 25% in corn oil. This substance has an s.g.of 1.274. The calculated LD50 is 7.77 g/kg for 100% substance.
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