Registration Dossier
Registration Dossier
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EC number: 240-212-2 | CAS number: 16068-37-4
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter
- other:
Reference
Description of key information
Adsorption/desorption:
[4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane]: Low potential for adsorption. log Koc = 1.1 (predicted)
[ 1,1,1,4,4,4-hexahydroxy-1,4-silabutane]: Low potential for adsorption. log Koc = -1.1 (predicted).
Key value for chemical safety assessment
- Koc at 20 °C:
- 12.6
Additional information
The substance hydrolyses at a moderate rate to substances which have low log Kow values (<3) and thus have low potential for adsorption, and the requirement for testing is waived. The parent substance itself also has a log Kow value <3.
However, for environmental exposure assessment of the parent substance, log Koc value of 1.1 at 20°C was determined using a validated QSAR estimation method.
For the silanol hydrolysis product, adsorption is predicted using the‘non-hydrophobics’ log Kow-based prediction method for log Koc developed by Sabljić and Güsten (1995) for the European Commission, and recommended in EU Guidance.
The relevant equation is:
Log Koc = 0.52log Kow + 1.02
Therefore, log Koc for the silanol hydrolysis product = -1.1 (Koc = approximately 0.1).
Reference:
Sabljić A and Güsten H (1995) QSARs for soil sorption. in: overview of structure-activity relationships for environmental endpoints. Hermens JLM (ed), report prepared wtihin the framework of the project “QSAR for prediction of fate and effects of chemicals in the environment”, an international project of the Environmental Technologies RTD programme (DG XII/D-1) of the European Commission under contract number EV5V-CT92-0211.
[LogKoc: 1.1]
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