Registration Dossier
Registration Dossier
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EC number: 823-780-1 | CAS number: 1034820-43-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Remarks:
- 5-day treatment study
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study well documented, meets generally accepted scientific principles, with very limited documentation
- Justification for type of information:
- Justification for Read Across is given in Section 13 of IUCLID
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- The toxicity of the substance was evaluated after repeated oral administration for 5 consecutive days.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Didodecyl 3,3'-thiodipropionate
- EC Number:
- 204-614-1
- EC Name:
- Didodecyl 3,3'-thiodipropionate
- Cas Number:
- 123-28-4
- Molecular formula:
- C30H58O4S
- IUPAC Name:
- Didodecyl 3,3'-sulfanediyldipropanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean of 383 g
No further details.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 500 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 5 000 mg/kg bw/day (actual dose received)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- No data.
- Positive control:
- No data.
Examinations
- Observations and examinations performed and frequency:
- No data.
- Sacrifice and pathology:
- No data.
- Other examinations:
- No data.
- Statistics:
- No data.
Results and discussion
Results of examinations
- Description (incidence and severity):
- No clinical signs were reported
- Description (incidence):
- No mortality was observed
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 5 000 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No mortality or clinical signs were reported.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOEL > 5000 mg/kg bw/day (actual dose received)
- Executive summary:
The toxicity of the substance after repeated dose was evaluated. For this reason the substance was orally admnistered to ten male rats for 5 concecutive days at doses of 50, 500 and 5000 mg/kg bw/day.
No mortality or clinical signs were reported.
NOEL > 5000 mg/kg bw/day (actual dose received)
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