Registration Dossier
Registration Dossier
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EC number: 271-845-2 | CAS number: 68609-96-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Glycidyloxy Compounds Used in Epoxy Resin Systems: A Toxicology Review
- Author:
- Gardiner Thomas H & al
- Year:
- 1 992
- Bibliographic source:
- REGULATORY TOXICOLOGY AND PHARMACOLOGY 15, S1 -S77 ( 1992)
Materials and methods
Test material
- Reference substance name:
- Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
- EC Number:
- 271-845-2
- EC Name:
- Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
- Cas Number:
- 68609-96-1
- Molecular formula:
- C11H22O2, C12H24O2, C13H26O2
- IUPAC Name:
- 2-[(decyloxy)methyl]oxirane; 2-[(octyloxy)methyl]oxirane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks on result:
- other: slight hyperemia of eyelid and conjunctiva
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The eye irritation potential of alkyl GEs has been tested in rabbits. C8-C10 elicited mild eye irritation and produced only slight to moderate conjunctivitis that cleared in 1 day.
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