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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February from 02 to 19, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
GLP compliance:
yes
Type of method:
flask method
Water solubility:
0.44 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
8.35 - 9.21
Details on results:
PRELIMINARY TEST
The preliminary test at room temperature showed that the water solubility of the test item was between 0.10 g/l and 1.03 g/l.

MAIN TEST
The water solubility at 20 °C and pH 8.35 - 9.21 of the test item was determined to be 0.44 g/l (RSD = 5.17 %).
To verify the accuracy of the analytical method a fresh prepared standard solution (prepared with the test item) was measured in between the samples of the flask method. The recovery rate of the measured standard solutions was in the range from 100.7 to 103.0 %, which shows a good accuracy of the analytical method.

Flask 1a 2a 3a 4a
pH value 8.35 9.21 9.00 6.02
Measured value [mg/l]

46.66

47.36

43.45

42.98

42.83

42.94

--

--
Average water solubility [mg/l] 470.14 432.14 428.84 --
Mean value of the water solubility [mg/l] 443.7 --
Standard deviation [mg/l] 22.95 --
Relative standard deviation [%] 5.17 --
Conclusions:
0.44 g/l at 20 °C and pH 8.35 - 9.21
Executive summary:

The water solubility of the test item was determined according to the method and procedures outlined into the OECD guideline 105. The preliminary test at room temperature showed that the water solubility of the test item was between 0.10 g/l and 1.03 g/l. For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice at 20 °C. To verify the accuracy of the analytical method a fresh prepared standard solution (prepared with the test item) was measured in between the samples of the flask method.

The recovery rate of the measured standard solutions was in the range from 100.7 to 103.0 %, which shows a good accuracy of the analytical method.

The water solubility at 20 °C and pH 8.35 - 9.21 of the test item was determined to be 0.44 g/l (RSD = 5.17 %).

Conclusion

0.44 g/l at 20 °C and pH 8.35 - 9.21

Description of key information

0.44 g/l at 20 °C and pH 8.35 - 9.21

Key value for chemical safety assessment

Water solubility:
0.44 g/L
at the temperature of:
20 °C

Additional information

OECD 105 - flask method