N,N-bis(2-hydroxyethyl)undec-10-enamide

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1963

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Principles of method if other than guideline:

Groups of 10 male NMRI mice were administered the test substance diluted in water at concentrations of 800 to 4200 mg/kg bw. Animals were then observed for clinical signs and mortality.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Species:

mouse

Strain:

NMRI

Sex:

male

Details on test animals or test system and environmental conditions:

Body weight: ca. 20 g

Route of administration:

oral: gavage

Vehicle:

water

Doses:

From 0 to 4200 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

None

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 2 700 mg/kg bw

Based on:

test mat.

Mortality:

As of 2000 mg/kg bw

Clinical signs:

Lying on the side or the back, cramps, uneven breathing, no reaction to noise or other stimulations.
Mortality was observed from 0.5 to 4 h after exposure.

Body weight:

Not evaluated.

Gross pathology:

Not evaluated.

Other findings:

Not evaluated.

None.

Interpretation of results:

GHS criteria not met

Conclusions:

Under the study conditions, the LD50 of the test substance in mouse was determined to be 2700 mg/kg bw.

Executive summary:

A study was conducted to determine the oral acute toxicity of the test substance, C11-unsatd. DEA (purity not specified). Groups of 10 male NMRI mice received a single dose of the test substance diluted in water by gavage at concentrations ranging from 800 to 4200 mg/kg bw. The animals were then observed for clinical signs and mortality. Under the study conditions, the LD50 of the test substance in mice was determined to be 2700 mg/kg bw (Ihlow, 1963).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 700 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

The available data for the test substance indicates a low potential for acute toxicity (oral LD50 >2,000 mg/kg bw). The substance therefore does not meet the requirement for classification according to CLP (EC 1272/2008) criteria.