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EC number: 276-123-0 | CAS number: 71873-46-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March from 07th to 19th, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 3.52 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.1 - 7.8
- Details on results:
- The recovery rate of the measured standard solutions was in the range from 97.5 to 103.6 %, which shows a good accuracy of the analytical method.
PRELIMINARY TEST
The preliminary test at room temperature showed that the water solubility of the test item was between 1.1 g/l and 7.8 g/l. - Conclusions:
- 3.52 g/l at 20 °C and ca pH 7.5
- Executive summary:
The water solubility of the test item was determined in accordance with method and procedures outlined in OECD guideline 105.
A preliminary test for solubility was carried out for the decision whether the column elution method or the flask method has to be used for the performance of the main test. The preliminary test at room temperature showed that the water solubility of the test item was between 1.1 g/l and 7.8 g/l; therefore, the flask method was used for the main test.
The concentration in the clear aqueous phase was determined by HPLC-UV validate method. The pH of each sample was recorded.
The water solubility of the test item was determined to be 3.52 g/l (RSD: 10.24 %) at 20 °C and pH between 7.1 - 7.8.
Conclusion
3.52 g/l at 20 °C and ca. pH 7.5.
Reference
Results of the flask method
| Flask | 1a | 2a | 3a | 4a |
measured value [mg/l] |
191.14 / 192.19 | 156.13 / 156.43 | 180.06 / 179.40 | -- / -- |
pH value at 24 °C |
7.5 | 7.1 | 7.8 | 6.1 |
average water solubility [g/l]* |
3.83 | 3.13 | 3.59 | -- |
mean value of the water solubility [g/l] |
3.52 | -- | ||
standard deviation [mg/l] |
0.36 | -- | ||
relative standard deviation [%] |
10.24 | -- | ||
* Considering the solution factor of 20
Measurement of a standard solution
| Standard solution, nominal value [mg/l] | Measured value [mg/l] | Repeatability [%] |
| Rep. 1 (215.6) | 221.09 | 102.5 |
| 218.91 | 101.5 | |
| 211.12 | 97.9 | |
| 210.20 | 97.5 | |
| Rep. 2 (250.4) | 259.30 | 103.6 |
| 256.56 | 102.5 | |
| 249.49 | 99.6 | |
| 250.85 | 100.2 |
Description of key information
3.52 g/l at 20 °C and ca. pH 7.5
Key value for chemical safety assessment
- Water solubility:
- 3.52 g/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - flask method
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