Registration Dossier
Registration Dossier
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EC number: 208-686-5 | CAS number: 538-23-8
Endpoint summary
Administrative data
Description of key information
Additional information
Data investigating the aquatic toxicity of Glycerol trioctanoate (CAS 538-23-8) are not available. Therefore, a read-across to structurally related substances with similar ecotoxicological profiles was conducted for the following endpoints: Short-term toxicity to fish, Short- and Long-term toxicity to aquatic invertebrates and Toxicity to aquatic algae and cyanobacteria. The toxicity control of the study on ready biodegradability was used to derive a value for Toxicity to microorganisms. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representatives for the assessment of the aquatic toxicity of the target substance. A detailed analogue approach justification is provided in the technical dossier (please refer to IUCLID Section 13).
For the endpoint short-term toxicity to fish, a read-across to the structurally related source substances Glycerol triheptanoate (CAS 620-67-7), Glycerides, C8-10 mono and di (CAS 85536-07-8) and Triglycerides, mixed decanoyl and octanoyl (CAS 73398-61-5) was conducted. Based on the available results from this read-across, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) shows no acute toxicity to fish up to the limit of saturation (lowest measured LC0≥53 mg/L).
For the endpoint short-term toxicity to aquatic invertebrates, a read-across to the structurally related source substances Glycerol triheptanoate (CAS 620-67-7), Glycerides, C8-10 mono and di (CAS 85536-07-8), and Decanoic acid, ester with 1,2,3-propanetriol octanoate (CAS 65381-09-1) was conducted. The lowest measured EC50 (48h) was determined as > 0.01 mg/L. Based on the available results from this read-across, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) shows no acute toxicity to aquatic invertebrates up to the limit of water solubility (< 0.532 µg/L at 20 °C).
For the endpoint long-term toxicity to aquatic invertebrates, a read-across to the structurally related source substances Glycerol triheptanoate (CAS 620-67-7), and Decanoic acid, ester with 1,2,3-propanetriol octanoate (CAS 65381-09-1) was conducted. The lowest NOEC (21 d) was determined as≥0.01 mg/L (immobility, reproduction). Based on the available results from this read-across, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) shows no long-term toxicity to aquatic invertebrates up to the limit of water solubility (< 0.532 µg/L at 20 °C).
For the endpoint Toxicity to aquatic algae and cyanobacteria, a read-across to the structurally related source substances Glycerol triheptanoate (CAS 620-67-7), Glycerides, C8-10 mono and di (CAS 85536-07-8), Decanoic acid, ester with 1,2,3-propanetriol octanoate (CAS 65381-09-1), and Triglycerides, mixed decanoyl and octanoyl (CAS 73398-61-5) was conducted. The lowest ErC 10 (72 h, nominal) was determined as > 0.449 mg/L. The lowest EC50 (72 h) was determined as > 10 µg/L. Based on the available results from this read-across, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) shows no toxicity to aquatic algae up to the limit of water solubility (< 0.532 µg/L at 20 °C).
For the endpoint Toxicity to microorganisms, a read-across to the structurally related source substance Glycerides, C8-10 mono and di (CAS 85536-07-8) was conducted. A NOEC for Toxicity to microorganisms was derived from a ready biodegradability study OECD 301B. Within 14 days, 81.1% biodegradation took place in this toxicity control clearly indicating the lack of toxic potential of Glycerides, C8-C10, mono- and di- to activated sludge microorganisms, and therefore, the test item concentration of 46.9 mg/L can be used as a NOEC. Based on the available results from this read-across, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) is non-inhibitory of aquatic microorganisms activity.
Based on the study results from available source substances, it can be concluded that Glycerol trioctanoate (CAS 538-23-8) is not toxic to freshwater organisms up to the limit of the water solubility (< 0.532 µg/L at 20 °C).
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