5-methylheptan-3-one oxime

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

there are no details on the method followed

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

5-methylheptan-3-one oxime

EC Number:

245-010-8

EC Name:

5-methylheptan-3-one oxime

Cas Number:

22457-23-4

Molecular formula:

C8H17NO

IUPAC Name:

5-methylheptan-3-one oxime

impurity 1

Reference substance name:

(E)-3,4-dimethylhexan-2-one oxime

IUPAC Name:

(E)-3,4-dimethylhexan-2-one oxime

impurity 2

Reference substance name:

(Z)-3,4-dimethylhexan-2-one oxime

IUPAC Name:

(Z)-3,4-dimethylhexan-2-one oxime

Test material form:

liquid

Specific details on test material used for the study:

Sample Marking: 76-362, Stemone

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

2.05 g/Kg
3.2 g/Kg
5.0 g/Kg
6.25 g/Kg

No. of animals per sex per dose:

10

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 800 mg/kg bw

Based on:

test mat.

95% CL:

>= 2 870 - <= 5 010

Any other information on results incl. tables

Dose (g/Kg)	Deaths / No. of Anmials	Observation Day
		1	2	3	4	5	6	7	8	9	10	11	12	13	14
2.05	1/10	0	1	0	0	0	0	0	0	0	0	0	0	0	0
3.2	5/10	3	1	0	0	1	0	0	0	0	0	0	0	0	0
5.0	8/10	7	1	0	0	0	0	0	0	0	0	0	0	0	0
6.25	7/10	2	5	0	0	0	0	0	0	0	0	0	0	0	0

Symptomatology

2.05 g/kg - lethargy, piloerection, flaccid;

3.2 g/kg -ataxia, lethargy, ptosis;

5.0 g/kg ataxia, loss of righting reflex;

6.25 g/kg - ataxia, lethargy, ptosis, piloerection

Necropsy	2.05 g/kg	3.2 g/kg	5.0 g/kg	6.25 g/kg
Liver blotchy	1	5	2	6
Lungs dark	0	4	8	7
Small intestine very red	0	3	5	2
blood around nose, mouth and eye	0	3	0	3
bloody urine	1	0	0	0

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 > 2000 mg/kg, therefore not classified for CLP

Executive summary:

An acute oral study was carried out on rats in high doses (>2000mg/Kg). The LD50 was determined to be 3.2 g/Kg, this is well above the category 4 classification limit of 2000 mg/Kg for CLP.