Registration Dossier
Registration Dossier
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EC number: 203-970-5 | CAS number: 112-42-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Screening test with basic information and result reporting. Appears valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The observation period was 7 days, and animals per dose was not according to guideline.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Undecan-1-ol
- EC Number:
- 203-970-5
- EC Name:
- Undecan-1-ol
- Cas Number:
- 112-42-5
- Molecular formula:
- C11H24O
- IUPAC Name:
- undecan-1-ol
- Details on test material:
- No data available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 215-260g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: undiluted
- Details on oral exposure:
- No detail available.
- Doses:
- 5010 mg/kg, 7940 mg/kg, 12600 mg/kg, 15800mg/kg
- No. of animals per sex per dose:
- 5010mg/kg; 1F, 7940mg/kg; 1F, 12600mg/kg; 1F, 15800mg/kg; 3M, 2F.
- Control animals:
- not specified
- Details on study design:
- Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. Observation period 7 days.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died.
- Clinical signs:
- other: Toxic signs included reduced appetite and activity and lethargy lasting two to three days.
- Gross pathology:
- Surviving animals were sacrificed seven days after dosing. The viscera appeared normal by macroscopic examination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The rat oral LD50 for undecyl alcohol was >15800 mg/kg. The study was not conducted according to GLP and the observation period was 7 days.
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