Registration Dossier
Registration Dossier
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EC number: 216-578-4 | CAS number: 1619-34-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction
- Guideline:
- other: REACH Guidance on (Q)SAR
- Principles of method if other than guideline:
- (Q)SAR
- Test organisms (species):
- other: Green algae
- Test type:
- other: (Q)SAR
- Water media type:
- freshwater
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 47.424 mg/L
- Dose descriptor:
- other: Chronic Value (ChV)
- Effect conc.:
- 13.501 mg/L
- Validity criteria fulfilled:
- yes
- Remarks:
- Aliphatic Amines: Maximum LogKow: 7.0 (Green Algae EC50) 7.0 (Chronic Value)
- Conclusions:
- Estimated EC50 : 47 mg/L
Estimated Chronic Value : 13 mg/L
Intermediate substance is estimated to be harmful to aquatic algae (Acute toxicity). - Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-07-07 1997-07-10
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: NFT 90-304
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- Bicrist OHquinu mélange reliquats divers 1ère partie
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Age of inoculum (at test initiation): 72 h
- Concentration: 1.6 E+6 c/ml - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- pH:
- 8.9
- Reference substance (positive control):
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 - < 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Conclusions:
- 10 mg/L< CEb50 - 72h <100 mg/L
Intermediate substance is considered to be harmful to aquatic algae (acute toxicity)
Referenceopen allclose all
Description of key information
Short-term toxicity:
ECOSAR 1.11: Green Algae: EC50 (96h): 47 mg/L
experimental data : 10 mg/L< CEb50 - 72h <100 mg/L
Long-term toxicity:
Indicated results for chronic toxicity are "Chronic values" as obtained from ECOSAR 1.11
ECOSAR 1.11: Green Algae: ChV: 13 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 13 mg/L
Additional information
NOEC could be estimated to around 9.1 mg/L (ChV/√2) as indicated in Practical Guide 5 - How to use and report (Q)SARs 3.0 (March 2016)
Intermediate substance is estimated to be harmful to aquatic algae (Acute Toxicity).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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