Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-122-3
CAS number: 106185-75-5
Individual values of skin reactions
Over 24-48-72 h
/ : no reading
The dermal irritation study was conducted
according to OECD guideline 404 in compliance with GLP. Three healthy
adult New Zealand white rabbits were exposed to 0.5 mL/rabbit of the
test item on clipped skin from the dorsal area for 4 hours in
semi-occlusive conditions. Skin reactions were observed at 1, 24, 48 and
72 h after removal of the substance until the disappearance of the
effects (day 7).1 hour after patch removal there was slight to well
defined erythema and oedema in all animals. Mean individual scores were
1.3, 1.0 and 0.3 for erythma and 1.0, 1.3 and 1.3 for oedema. The
reactions were reversible within 5 days (D6) for two animals and 6 days
(D7) for the third rabbit.
Therefore, the test item should not be
classified as irritating to the skin according to the criteria of
directive n°67/548/EEC and CLP regulation (EC) n°1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again