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EC number: 942-523-5
CAS number: -
The test substance is not considered
sensitizing to the skin
In a BUEHLER test study performed according
to OECD TG 406 under GLP conditions, the skin sensitizing potential of
the test substance was assessed on the skin of guinea pigs (Bioassay,
2017). Based on two preliminary range-finding tests, 20 animals were
exposed (epicutaneous, occlusive) to 5% for the induction phase and 2%
for the challenge of the test substance prepared dionized water. The
control group consisted of 10 animals. In the test group 12 animals
showed discrete erythema (grade 1) after the first induction, while 14
animals showed discrete or moderate erythema (grade 1 or 2) after the
second induction. 20 animals showed discrete or moderate erythema after
the third induction. After the challenge 1 animal in total showed
discrete erythema (grade 1). Based on these results, it was concluded
that the test substance does not have a sensitizing effect on the skin
of the guinea pig in the BUEHLER Test under the test conditions chosen.
Based on the available information
classification for skin sensitisation is not warranted in accordance
with EU Classification, Labeling and Packaging of Substances and
Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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