Registration Dossier
Registration Dossier
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EC number: 457-690-5 | CAS number: 23432-65-7
Endpoint summary
Administrative data
Description of key information
Additional information
The registered (parent)substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) hydrolyses rapidly under environmental relevant conditions (DT50 = 1.9 h at pH 7 and 20-25 °C; QSAR) to the hydrolysis products methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate and methanol (CAS 67-56-1). The ECHA guidance R.16 states that “for substances where hydrolytic DT50 is less than 12 h, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself” (ECHA, 2016). The ECHA guidance R.16 also suggests that in cases where the hydrolysis half-life is less than 12 h, the breakdown products, rather than the parent substance, should be evaluated for aquatic toxicity. Thus, the environmental fate assessment in this dossier is based on the hydrolysis products.
The parent substance is characterized by a predicted water solubility of 4.9 x 104mg/L (at 20 - 25 °C, QSAR) and is not readily biodegradable (OECD 301 F). It has a low measured vapour pressure of 0.011 hPa (25°C, EU method A.4) and thus exhibits low volatility. Therefore, indirect photodegradation is not an important degradation pathway. Furthermore, it has a predicted log Kow of 1.1 (QSAR), indicating a low potential for adsorption to soil and sediment. Considering the low potential for adsorption to soil and sediment and the high water solubility, the main compartment for environmental distribution will be water.
Silanol hydrolysis product methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate
The silanol hydrolysis product is characterized by a predicted water solubility of 1.0E+06 mg/L (20 -25°C, QSAR) and a low predicted vapour pressure of 4.1 x 10-3Pa (25°C, QSAR), indicating low volatility. Therefore, indirect photodegradation is not an important degradation pathway. There is no evidence of any significant biodegradation. However, its potential for bioaccumulation and its affinity to soil and sediment is low based on its low, predicted log Kow of -1.9 (QSAR).
Methanol
The alcohol hydrolysis product methanol is well characterized in the public domain.Methanol is water miscible at 20 °C, exhibits a low log Kow (-0.82 to -0.64) but a considerably higher vapour pressure (12790 Pa at 20 °C) than the silanol hydrolysis product (values taken from SIDS InitialAssessment Report for Methanol, OECD, 2004). In consequence, volatility of methanol from water can be expectedwith about 73 % of environmental methanol distributing to air and 16 % to water.Additionally, methanol is considered to be readily biodegradable. Bioaccumulation of methanol is expected to be low in fish (OECD SIDS, 2004).
References:
OECD SIDS, 2004: SIDS Initial Assessment Report for Methanol, SIAM 19, Berlin, Germany, 19-22 October 2004, Methanol, CAS 67-56-1Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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