Registration Dossier
Registration Dossier
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EC number: 203-406-8 | CAS number: 106-52-5
Endpoint summary
Administrative data
Description of key information
Biodegradation
in water:
The
screening test inherent to the biodegradability of the substance was
calculated using seven different Biowin 1-7 models of the BIOWIN v4.10
software. The results indicate that 4-Piperidinol, 1-methyl- is expected
to be readily biodegradable in water.
Biodegradation
in water and sediment:
Estimated
half life of 4-Piperidinol, 1-methyl- in water was 15 days (360 h) and
in sediment estimated to be 135 days (3240 h).
Biodegradation
in soil:
Biodegradation
half-life of test substance 4-Piperidinol, 1-methyl- in soil was
estimated to be 30 days (720 hrs).
Additional information
Biodegradation in water:
Data for the test compound 4-Piperidinol, 1-methyl-(CAS No. 106-52-5) and the studies for its read across substance were reviewed for the biodegradation end point which is summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 4 -Piperidinol, 1 -methyl- (CAS no. 106 -52 -5) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 4-Piperidinol, 1-methyl- is expected to be readily biodegradable in water.
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound 4 -Piperidinol, 1 -methyl-(CAS no. 106 -52 -5).The screening test inherent to the biodegradability of the substance was calculated using the software BIOWIN v4.10. The results indicate that 4-Piperidinol, 1-methyl- is expected to be readily biodegradable.
For supporting study of RA CAS No.105-59-9; Biodegradation study was conducted for evaluating the percentage biodegradability of test substance N-Methyldiethanolamine (SIDS INITIAL ASSESSMENT PROFILE, CoCAM2, Pg. no. 17-19, April 2012). The study was performed according to OECD Guideline 301 A. The percentage degradation of test substance was determined to be 96% after 18 days. Thus, the substance N-Methyldiethanolamine is expected to be readily biodegradable in water.
Further an experimental study for same RA CAS No. 105-59-9 was reported. In this study, the aerobic biodegradability of the chemical N-Methyldiethanolamine (MEDA; CAS No. 105-59-9) was investigated in a standardised continuous flow experiment for a period of 28 days. The parameter TOC was used for determination of degradation during the experiment. MDEA was determined by gas-chromatography fit-ted with a flame ionisation detector) The continuous flow experiment showed a very good biodegradability of the waste water including for high concentrations of MDEA-solution with a TOC-removal of 96%. That implies that the MDEA-solution added to the waste water of the gas sweetening plant was readily biodegradable in nature.
On the basis of above results for target and read across substance, it can be concluded that the test substance 4-Piperidinol, 1-methyl-can be expected to be readily biodegradable in nature.
Biodegradation
in water and sediment:
Estimation
Programs Interface (EPI) Suite (2016) prediction model was run to
predict the half-life in water and sediment for the test compound
4-Piperidinol, 1-methyl- (CAS No. 106 -52 -5). Half life period of
4-Piperidinol, 1-methyl- in water isestimated to be 15 days (360 hrs),
while in sediment it is 135 days (3240 hrs). Based on these half life
values of 4 -Piperidinol, 1 -methyl-, it is concluded that the chemical
is not persistent in water but persistent in sediment.
Biodegradation
in soil:
Based
on EPI prediction Level III Fugacity Model (EPI suite, 2016), the
estimated half-life period of 4-Piperidinol, 1-methyl- (CAS No. 106 -52
-5) in soil was obtained to be 30 days (720 hrs). Based on this
half-life value of 4-Piperidinol, 1-methyl-, it isconcluded that the
chemical is not persistent in the soil environment.
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