Registration Dossier
Registration Dossier
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EC number: 233-032-0 | CAS number: 10024-97-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of subchronic intermittent exposure to nitrous oxide in Swiss Webster mice
- Author:
- Rice SA, Mazze RI, Baden JM
- Year:
- 1 985
- Bibliographic source:
- J environm Path Toxicol 6: 271–281 cited in 'Nitrous oxide [MAK Value Documentation, 1993]'
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Swiss Webster mice (15/sex/gp) were exposed to N2O via whole body inhalation at concentrations of 0, 5000, 50000 or 500000 ppm [0, 0.5, 5, 50%] for 4/h/d, 5d/wk over 14 wks.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dinitrogen oxide
- EC Number:
- 233-032-0
- EC Name:
- Dinitrogen oxide
- Cas Number:
- 10024-97-2
- Molecular formula:
- N2O
- IUPAC Name:
- nitrogen oxide
- Test material form:
- gas
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of exposure:
- 4 h
- Concentrations:
- 0, 5000, 50000 and 500000 ppm (0.5, 5, 50 %)
- No. of animals per sex per dose:
- 27
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 909 091 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 500 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No animal died during the course of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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