Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Endpoint summary
Administrative data
Description of key information
6-chlorohexyl methacrylate is expected to be of low acute toxicity for all routes based on its similarity with short chain alkyl methacrylates.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Read-across with similar substances based on information reported SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Read-across with similar substances based on information reported SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004).
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Read-across with similar substances based on information reported SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004).
Additional information
No experimental data is available regarding acute toxicity of 6-chlorohexyl methacrylate (6-CHMA).
A low acute toxicity for 6-chlorohexyl methacrylate (6-CHMA) is expected also based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
Oral exposure:
No data is available for acute oral toxicity of 6-chlorohexyl methacrylate (6-CHMA). No classification regarding acute oral toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for these similar compounds. In fact the oral LD50 for all the methacrylic ester of this category is greater than 2000 mg/kg/bw. In particular, experimental data are available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6. In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2 -EHMA a study conducted in 1998 according to OECD 401 is reported: LD50 rat for 2-EHMA > 2000 mg/kg bw. (Ref. Furuhashi et all, 1998, Single Dose Oral Toxicity Study of 2-Ethyl Hexyl Methacrylate in Rats (English summary). Nihon Bioresearch Inc. Hashima Laboratory, Unpublished report on behalf of Ministry of Health and Welfare, Japan).
Inhalation exposure:
No data is available for acute inhalation toxicity of 6-chlorohexyl methacrylate (6-CHMA). No classification regarding acute inhalation toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004)for these similar compounds. In fact, inhalation LD 50 for ethyl methacrylates CAS 97-63-2 and for n-Butyl methacrylate CAS 97-88-1 is in excess of 29 mg/l (Ref. Kelly, 1993, Inhalation median lethal concentration (LC50) studies with methacrylates in rats ; methacrylic acid, butyl methacrylate, ethyl methacrylate and methyl methacrylate. E.I. du Pont de Nemours and Company, Haskell Laboratory, Unpublished report No. DuPont HLR 400-93 on behalf of Methacrylates Producers Association (MPA) ). Although acute inhalation data are not available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6, this end-point is not considered critical due to its low vapor pressure (<1 hPa @ 20 °C).
Dermal exposure:
No data is available for acute dermal toxicity of 6-chlorohexyl methacrylate (6-CHMA). No classification regarding acute dermal toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for these similar compounds . In fact, based on experimental study conducted in 1993 according to OECD 402 LD50 rabbit > 2000 mg/kg/bw for n-Butyl methacrylates CAS 97-88-1 (Ref. Sarver JW, 1993, Acute oral toxicity study with n-butyl methacrylate in rabbits. Haskell Laboratory Report No. 818-92, unpublished report, study on behalf of Methacrylate Producers Association).
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), no classification is suggested for acute toxicity of 6-chlorohexyl methacrylate (6-CHMA) for oral, inhalation and dermal route based on information available for the similar compounds short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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