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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
1., 2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
1. No data available
2. Structure estimation method
3. No data available
Temp.:
55 °C
Remarks:
1. The study was performed at pH range 5-9, respectively.
Remarks:
2. The study was performed at pH 7 and 8, respectively.
Remarks:
3. Details not known
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Temp.:
55 °C
DT50:
> 29 - < 146 d
Remarks on result:
other: 1. The study was performed at pH range 5-9, respectively.
pH:
7
DT50:
5 yr
Type:
second order
Remarks on result:
other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec
pH:
8
DT50:
200 d
Type:
second order
Remarks on result:
other: 2. Hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
38 d
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: 3. Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

In an another study, the base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

For the test chemical, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

In an another study, the base catalyzed second order hydrolysis rate constant and half-life value of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant was determined to be 0.04 L/mol-sec with a corresponding half-life of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec. The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 5 yrs, at pH range 5-9, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.