Registration Dossier
Registration Dossier
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EC number: 223-358-1 | CAS number: 3852-09-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- An in vitro study was not conducted since an in vivo study was already available. The in vivo study was conducted in 1990.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl 3-methoxypropionate
- EC Number:
- 223-358-1
- EC Name:
- Methyl 3-methoxypropionate
- Cas Number:
- 3852-09-3
- Molecular formula:
- C5H10O3
- IUPAC Name:
- methyl 3-methoxypropanoate
- Details on test material:
- - clear colourless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms Ltd., Petersfield, Hampshire, UK
- Age at study initiation: 11-13 weeks
- Weight at study initiation: 2.4-3.0 kg prior to treatment on day 1
- Housing: individually housed
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 19
- Humidity (%): 30-70
- Air changes (per hr): approximately 19
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 10 cm2
REMOVAL OF TEST SUBSTANCE
- Washing: with water
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritant / corrosive response data:
- Very slight erythema only was observed in 3 animals following the removal of the dressings on day 1 and for the following 2 days. All reactions had resolved by day 4. There was no response to treatment in the remaining 3 animals.
Applicant's summary and conclusion
- Conclusions:
- A single semi-occlusive application of methyl-3-methoxy propionate to intact rabbit skin for 4 hours elicited transient mild dermal irritation.
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