Registration Dossier
Registration Dossier
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EC number: 700-316-5 | CAS number: 1155405-88-1
Endpoint summary
Administrative data
Description of key information
The substance is practically non-toxic after acute exposition.
LD50 oral > 2000 mg/kg
LD50 dermal > 2000 mg/kg (based on read-across)
Key value for chemical safety assessment
Additional information
The LD50 oral of the test substance Tri-C18-22 (even numbered)-alkyl 2-hydroxypropane-1,2,3-tricarboxylate was > 2000 mg/kg. This result was supported with data available from two different studies demonstrating a lack of toxic effects up to doses far above the limit dose as recommended by current regulatory guidelines. No mortalities or any toxic effects in rats after administration of doses up to 50000 mg/kg were observed.
The acute dermal toxicity of Tri-C18-22 (even numbered)-alkyl 2-hydroxypropane-1,2,3-tricarboxylate not specifically determined. However, data are available for a structrurally related substance Tri (hexyl, octyl, decyl) citrate with the only difference in the shorter carbon chain length of the ester groups. The LD50 dermal of the structurally related substance was > 2000 mg/kg.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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