Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic algae up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of Diisooctadecyl malate (CAS 67763-18-2) to aquatic algae are not available. The assessment was therefore based on studies conducted with the structurally similar substance bis(C12-C13)alkyl-2-hydroxybutandioate (CAS 149144-85-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The toxicity of bis(C12-C13)alkyl-2-hydroxybutandioate (CAS 149144-85-4) to algae was evaluated in in a limit test was conducted according to OECD 201, under GLP conditions (Biffi, 1993). Selenastrum capricornutum was exposed to the test substance for 72 hours at test substance concentration of 100 mg/L (WAF). An EC50 (72 h) >100 mg/L was determined at test termination.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Diisooctadecyl malate is not acutely toxic to algae up to the limit of water solubility.
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