Registration Dossier
Registration Dossier
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EC number: 248-324-3 | CAS number: 27206-35-5
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RTECS data are peer-reviewed.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Reproductive data (RTECS Number: KI7968000)
- Author:
- RTECS
- Year:
- 1 990
- Bibliographic source:
- http://ccinfoweb2.ccohs.ca/rtecs/Action.lasso?-database=rtecs&-layout=Display&-response=detail.html&-op=eq&RTECS+NUMBER=KI7968000&-search
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mesna was administered to rats intravenously during days 7-17 of gestation. Lactating females were exposed 21 days post-birth. Effects on newborns and foetotoxicity effects were evaluated.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mesna
- EC Number:
- 243-285-9
- EC Name:
- Mesna
- Cas Number:
- 19767-45-4
- Molecular formula:
- C2H6O3S2.Na
- IUPAC Name:
- sodium 2-sulfanylethanesulfonate
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Remarks on result:
- not measured/tested
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- dose level: TDLo
- Effect level:
- 10 400 mg/kg bw (total dose)
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The lowest toxic dose (TDLo) of 10400 mg/kg bw (total dose) was reported for mesna.
- Executive summary:
Mesna was administered to female rats intravenously during days 7-17 of gestation and effects on newborn rats and foetotoxicity were evaluated.
Mesna caused no deaths of foetuses. One stunted foetus was observed. Physical effects on newborns were reported (without details). The lowest toxic dose ((TDLo) of 10400 mg/kg bw (total dose) was reported.
Mesna is a suitable Read-Across substance for SPS as Dimesna and Mesna could be considered a metabolite of each other, which allows the conclusion that the same also applies for SPS and MPS, and their respective alkyl side chains differ only in one –CH2- group. This is in detail outlined in the read-across justification. Hence, it can be concluded that the derived results are applicable for SPS, too.
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