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Diss Factsheets
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EC number: 265-779-3 | CAS number: 65443-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence approach using experimental study (OECD Guideline 301D, no-GLP) and QSAR data (Biowin v4.10):
Not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
To assess the ready biodegradability of the registered substance, a weight of evidence approach was used based on one experimental study and one QSAR.
The experimental study (AkzoNobel, 2012) was performed on the registered substance according to OECD Guideline 301D but without GLP statement. The test substance (at 2 mg/L) was exposed to two inocula, activated sewage sludge microorganisms and river water, with culture medium in closed bottles in the dark at 22-24°C for 7, 14, 21, 28, 42, 56 and 84 days. The degradation of the test substance was assessed by the measurement of oxygen consumption. According to the results of this study, the test substance is partially degradable. The test substance undergoes 14-21% and 51-55% biodegradation after 28 and 84 days, respectively, depending on the inoculum used. Thus, the test substance should be regarded as not readily biodegradable according to this test. However, the degradation observed strongly suggests that it is primarily biodegradable within 28 days.
The QSAR data was performed on the registered substance. The model used is Biowin v4.10, plug-in from EPISUITE v4.1 from US EPA. This model is recommended by the ECHA guidance document on information requirements and is well documented with regard to validation parameters according to OECD principles. Moreover, the substance is fully characterised for the applicability domain. The Biowin 3 result is "weeks-months", therefore it's expected that the substance is not readily biodegradable but this result nevertheless supports the conclusion that biodegradation of the substance can be anticipated over time.
In conclusion, as we obtained the same results between the experimental and the predicted data, we can conclude, based on this weight of evidence approach that the registered substance is not readily biodegradable but that the degradation observed strongly suggests that it is primarily biodegradable within 28 days.
In addition, in a preliminary biodegradability test performed on the registered substance and available in the bioaccumulation study report (Kyushu, 1986), no sign of possible biodegradability was observed at 100 ppm of test substance. This test was performed in July 1980 by Chemical Inspection & Testing Institute, Japan, and is considered as non official since the test was not done following official standard method.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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