1,4-divinylbenzene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database.

Data source

Reference

Reference 1

Reference Type:

other: authoritative database

Title:

Acute Dermal toxicity - Test chemical

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

ChemIDplus

Reference 2

Reference Type:

secondary source

Title:

Toxicity Study

Author:

NTRL

Year:

1990

Bibliographic source:

NTRL

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute dermal toxicity of test chemical in rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-Ethenylphenyl acetate

EC Number:

607-905-5

Cas Number:

2628-16-2

Molecular formula:

C10H10O2

IUPAC Name:

4-Ethenylphenyl acetate

Details on test material:

- IUPAC Name: 4-Ethenylphenyl acetate- InChI: 1S/C10H10O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h3-7H,1H2,2H3- Smiles: O=C(Oc1ccc(cc1)C=C)C- Molecular formula :C10H10O2- Molecular weight :162.187 g/mole- Substance type:Organic- Physical state:Liquid

Test animals

Species:

rat

Strain:

other: CD rat

Sex:

male/female

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE - Area of exposure: clipped skin - % coverage: The material was spread over a 5 x 5 cm area - Type of wrap if used: The material was covered with gauss and then an impermeable bandage. REMOVAL OF TEST SUBSTANCE - Washing (if done): The dressing was removed and the remaining material removed with a wet towel. - Time after start of exposure:24 hours

Duration of exposure:

24 hours

Doses:

2000 mg/kg

No. of animals per sex per dose:

groups of 5 rats of each sex

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, animals were sacrificed on the 14th day after removal of the test substance, and submitted to a necropsy for detection of possible macroscopic effects on the major organs.- Other examinations performed: Animals were observed for mortality, clinical signs and body weight changes.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality was observed

Mortality:

No mortality was observed at 2000 mg/kg bw.

Clinical signs:

No adverse clinical signs were reported and the application site was free of local irritation throughout the 14 day observation period.

Body weight:

Animals gained bodyweight normally.

Gross pathology:

All organs appeared normal on necropsy.

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

Acute dermal toxicity dose (LD50) value was considered to be >2000 mg/kg bw, when groups of 5 CD rats of each sex were treated with test chemical by dermal application occlusively.

Executive summary:

Acute dermal toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 2000 mg/kg bw. The material (neat) was spread over a 5 x 5 cm area of clipped skin and covered with gauss and then an impermeable bandage. The material was left on the skin for 24 hours after Which the dressing was removed and the remaining material removed with a wet towel. Animals were observed for 14 days after removal of the dressing, were sacrificed on the 14^thday after removal of the test substance, and submitted to a necropsy for detection of possible macroscopic effects on the major organs.No mortality was observed at 2000 mg/kg bw. No adverse clinical signs were reported and the application site was free of local irritation throughout the 14 day observation period.Animals gained bodyweight normally. All organs appeared normal on necropsy. Hence, LD50 value was considered to be >2000 mg/kg bw, when groups of 5 CD rats of each sex were treated with test chemical by dermal application occlusively.