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EC number: 931-468-2 | CAS number: 1190625-94-5
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility 0.026 mg/L (0.000026 g/L) at 20 °C; OECD 105, EU Method A.6 and EPA OPPTS 830.7840
Key value for chemical safety assessment
- Water solubility:
- 0.026 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7840 under GLP conditions using the flask method. The study was awarded a reliability score of 1 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997).
Following a preliminary study in which the slow-stirring flask method was chosen for the main study, three containers were filled with 100 mL double distilled water. A volume of 10 µL of the test material was added to the glass vessels avoiding turbulent mixing of the two phases. The vessels were placed on a magnetic stirring device at 29.8 ± 0.1 °C where the content of each vessel was gently stirred at 100 rpm for 24, 48 or 72 hours. As the blank, 100 mL double distilled water was stirred for 72 hours. After this stirring period, the containers were placed on a magnetic stirring device at 20.0 ± 0.3°C where the content of each vessel was gently stirred at 100 rpm for 30 hours.
After the stirring period, subsamples of the water phase were taken directly from the flasks and diluted in a 1:1 (v:v) ratio with methanol and analysed by UPLC-MS/MS.
The 72-hour measurement was significantly lower than the 48- and 24-hour measurements (maximum difference (MD) > 15 %). Based on this, the water solubility of the test material was given as the mean value of the measurements at 24 and 48 hours. The large resemblance between the analysed concentrations in the 24- and 48-hour water solubility samples (i.e. maximum difference of 11 %) indicates that the system was in equilibrium after these stirring periods. No test material was detected in the pre-treated sample from the blank water mixture.
Under the conditions of this study, the water solubility of the test material was determined to be 0.026 mg/L (0.000026 g/L) at 20 °C and pH 7.0.
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