Registration Dossier
Registration Dossier
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EC number: 283-952-1 | CAS number: 84776-27-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinchona officinalis, Rubiaceae.
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ChemIDplus Advanced
- Author:
- U.S. National Library of Medicine
- Year:
- 2 013
- Bibliographic source:
- http://chem.sis.nlm.nih.gov/chemidplus/
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): quinine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 68 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further data
Applicant's summary and conclusion
- Conclusions:
- The LD50 of the read across substance quinine for mouse is 68 mg/kg bw.
- Executive summary:
The acute toxicity of the read across substance quinine was tested via an intravenous injection. From this study it is shown that the LD50, tested on mouse is 68 mg/kg bw. It is considered as harmful according to EU criteria. Therefore, we conclude that totaquina, which consists of 75% quinine, is harmful.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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