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EC number: 700-319-1 | CAS number: 117646-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 11 August 2015 and 08 September 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1= Reliable without restriction o GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-{2-[(2-ethylhexyl)oxy]ethoxy}ethyl prop-2-enoate
- Cas Number:
- 117646-83-0
- Molecular formula:
- C15H28O4
- IUPAC Name:
- 2-{2-[(2-ethylhexyl)oxy]ethoxy}ethyl prop-2-enoate
- Test material form:
- other: liquid
- Details on test material:
- Identification:
M120
Batch:
NC-5635-01
Purity:
99.4%
Physical state/Appearance:
Clear colorless liquid
Expiry Date:
05 October 2015
Storage Conditions:
Room temperature, in the dark
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.5 mg/L
- Conc. based on:
- test mat.
Any other information on results incl. tables
Range Finding Test
No immobilization was observed at the test concentrations of 0.10 and 1.0% v/v saturated solution, however, immobilization was observed at 10 and 100% v/v saturated solution.
Based on this information test concentrations of 2.6, 6.4, 16, 40 and 100% v/v saturated solution were selected for the definitive test.
Chemical analysis of the test preparations at 0 hours (see Appendix 6) showed measured test concentrations to range from less than the LOQ to 20.4 mg/L. Analysis at 48 hours showed measured test concentrations to range from 0.226 to 22.7 mg/L. There was no significant change in the measured concentrations at 48 hours indicating that the test item was stable under test conditions.
Definitive Test
Varification of test Concentrations
Analysis of the test preparations at 0 hours (see Appendix 6) showed measured test concentrations to range from 3.38 to 21.7 mg/L. There was no significant change in the measured concentrations at 48 hours and so the results are based on 0-Hour measured test concentrations only.
Immobilization Data
Analysis of the immobilization data by Probit analysis using Linear Maximum-Likelihood regression 0-Hour measured test concentrations gave the following results:
Time (h) |
EC50(mg/L) |
24 |
6.7 |
48 |
6.5 |
The No Observed Effect Concentration after 24 and 48 hours exposure was 3.4 mg/L. The Lowest Observed Effect Concentration after 24 and 48 hours exposure was 7.6 mg/L.
The slopes and their standard errors of the response curves at 24 and 48
hours were
1.16 (SE = 0.25) and 1.13 (SE = 1.0) respectively. Due
to the nature of the data it was not possible to calculate the 95%
Confidence Limits at 24 and 48 hours.
Sub-Lethal Effects
No sub-lethal effects of exposure were observed throughout the test.
Validation Criteria
The test was considered to be valid given that none of the control daphnids showed immobilization or other signs of disease or stress and that the oxygen concentration at the end of the test was equal to or greater than 3 mg/L in the control and test vessels.
Water Quality Criteria
Temperature was maintained at approximately 21 °C throughout the test, while there were no treatment related differences for oxygen concentration or pH.
Throughout the test the light intensity was observed to be in the range 649 to 671 Lux.
Observations on Test Item Solubility
At the start and throughout the test all control and test solutions were observed to be clear colorless solutions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Exposure of Daphnia magna to the test item has been investigated and gave the following results based on the 0-Hour measured test concentrations:
EC50 = 6.5 mg/L
NOEC = 3.4 mg/L
LOEC = 7.6 mg/L
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