Registration Dossier
Registration Dossier
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EC number: 810-200-7 | CAS number: 1050477-45-6
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- GLP compliance:
- no
- Type of method:
- thermal analysis
- Remarks:
- Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)
- Melting / freezing pt.:
- 157.6 °C
- Remarks on result:
- other: average of four determinations
- Conclusions:
- The melting point of Carboxy-TH-naphthyridin is determined as 157.6 °C. Atmospheric pressure is assumed.
- Executive summary:
A DTA/DSC system was used to determine the melting point in accordance to test method A.1 (section 1.4.4), „determination of the melting point“, described in the EC-Guideline. Carboxy-TH-naphthyridin is closed up in a crucible made of aluminum and heated up in a DTA/DSC system (heating rate 1 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect are recorded.
Carboxy-TH-naphthyridin is melting at 157.6 °C (average of four determinations) and no pressure is reported. The test item recrystallized after the melting process. A second heating could not reproduce the melting point which indicates a chemical transformation of the test item. This assumption is supported by the light orange coloured melt (open crucible) and by the orange melt (closed crucible) in the crucible.
Reference
The test item recrystallized after the melting process. A second heating could not reproduce the melting point which indicates a chemical transformation of the test item. This assumption is supported by the light orange coloured melt (open crucible) and by the orange melt (closed crucible) in the crucible.
Description of key information
The melting point of Carboxy-TH-naphthyridin is determined as 157.6 °C. Atmospheric pressure is assumed.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 157.6 °C
Additional information
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