Phosphonium, (3-methyl-4-oxo-2-buten-1-yl)triphenyl-, chloride (1:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented study, but borderline result, more animals should have been used

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1993

Materials and methods

Test guideline

Qualifier:

no guideline available

Deviations:

not applicable

Principles of method if other than guideline:

see summary

GLP compliance:

no

Test type:

other: limit test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride

EC Number:

609-124-5

Cas Number:

3541-81-9

Molecular formula:

C23 H22 O P . Cl

IUPAC Name:

Phosphonium, (3-methyl-4-oxo-2-butenyl)triphenyl-, chloride

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

first 400 mg/kg bw, second treatment 350 mg/kg bw

No. of animals per sex per dose:

2 per per dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD100

Effect level:

350 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:

toxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

substance is toxic

Executive summary:

Three males and 2 females were found dead (resp. sacrificed by humane reasons) within a few hours after the single oral administration of 400 mg/kg. Because of the high mortality 24 hours after scheduled treatment 4 additional animals (2 M

+ 2 F) were treated with a single oral administration of 350 mg/kg.The animals received each a single oral dose by gavage and were observed for a period of two weeks after dosing.

Single dose administrations of 350 mg/kg induced piloerection and/or sedation in most treated animals within a few hours after

dosing. Half of the animals died (or were sacrificed moribund) within a few hours after treatment. No further mortalities occurred nor were there further clinical symptoms noted during the 14-day observation period. The animals showed normal body weight development. No clearcut macroscopic findings were observed at scheduled necropsy.