Icosyl methacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1975

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: OSHA Toxicity Screening Test. Limited documentation of the study. No detailed description of the test substance available.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Guideline:

other: OSHA Toxicity Screening Test

GLP compliance:

no

Remarks:

pre-GLP

Test type:

other: single dose

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dodecyl pentadecyl methacrylate

IUPAC Name:

Dodecyl pentadecyl methacrylate

Test material form:

other: liquid

Details on test material:

No more data available.

Test animals

Species:

rat

Strain:

other: Charles River

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: 80 L
- Method of holding animals in test chamber: no data
- Source and rate of air: air flow: 4.12 L/min
- Method of conditioning air: The vapor was generated by bubbling a stream of clean, dry air (-40 °C dewpoint) through the undiluted test material in a gas washing bottle. The resulting air-vapor mixture was introduced into the exposure chamber.
- System of generating particulates/aerosols: -
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: 25 °C, atmospheric pressure: 30.12 inches Hg

Duration of exposure:

1 h

Concentrations:

1.42 mg/L air nominal concentration

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC0

Effect level:

> 1.42 mg/L air

Based on:

test mat.

Remarks:

nominal

Exp. duration:

1 h

Mortality:

No mortality was observed (0/10 male rats)

Body weight:

Weight gain male: 102 g (within the normal limits).

Gross pathology:

No gross pathologic alterations observed at the end of 14-day observation period.

Any other information on results incl. tables

The average 2-week body weight gains were within the normal limits. Necropsy, performed on all rats at the end of the 14-day observation period, did not reveal any gross pathologic alterations.

Applicant's summary and conclusion

Conclusions:

In an acute inhalative toxicity study with Dodecyl pentadecyl methacrylate with male Charles River rats, an LC0 > 1.42 mg/L air (0/ 10 animals died) was observed.

Executive summary:

In an acute inhalative OSHA toxicity screening test with Dodecyl pentadecyl methacrylate (purity: unknown), the test substance was administered for one hour in a concentration of 1.42 mg/L air to 10 male Charles river rats. There were no signs of intoxication reported within the 14-day observation period. No mortality, normal 2-week body weight gain. Necropsy, performed on all rats at the end of the study, did not reveal any gross pathologic alterations.

The determined LC0 was > 1.42 mg/L air in male Charles river rats.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose