Registration Dossier
Registration Dossier
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EC number: 607-233-2 | CAS number: 2343-89-7
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1/4/15 to 2/7/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A recent study, conducted according to an OECD guideline and GLP standards.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Test temperature:
- 25 ºC
- Details on study design: HPLC method:
- HPLC System: Agilent Technologies 1200 Series
Detector Type: Variable Wavelength Detector (VWD)
Column: Phenomenex Luna 5μ CN 100Å (150 x 4.6 mm internal diameter)
Column Temperature: 25 ºC
Mobile Phase: Methanol:Purified Water (55:45 v/v)
pH of Mobile Phase: 6.7
Flow-Rate: 1.0 ml/min
Injection Volume: 10 μL
VWD Wavelength: 210 nm - Type:
- Koc
- Value:
- < 17.8
- Temp.:
- 25 °C
- Type:
- log Koc
- Value:
- < 1.25
- Temp.:
- 25 °C
- Details on results (HPLC method):
- - Details of fitted regression line (log k' vs. log Koc): y=0.4042x - 1.1346, R^2 = 0.9819
- Average retention data for test substance: 2.394 - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be less than 17.8, log10 Koc less than 1.25. These values indicate that the test item will have a very high mobility in the environment.
- Executive summary:
The adsorption coefficient has been determined to be less than 17.8, log10 Koc less than 1.25, using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. These values indicate that the test item will have a very high mobility in the environment.
Reference
Retention times and Log10 Koc values of reference standards:
| Standard | Mean Retention Time (mins) | Log10 Koc |
| Acetanilide | 2.437 | 1.25 |
| Phenol | 2.410 | 1.32 |
| Atrazine | 2.828 | 1.81 |
| Isoproturon | 3.020 | 1.86 |
| Aniline | 3.202 | 2.07 |
| Triadimenol | 3.503 | 2.40 |
| Linuron | 3.717 | 2.59 |
| Naphthalene | 4.597 | 2.75 |
| Endosulfan-diol | 4.150 | 3.02 |
| Fenthion | 5.986 | 3.31 |
| alpha-Endosulfan | 8.880 | 4.09 |
| Diclofop-methyl | 8.839 | 4.20 |
| Phenanthrene | 8.294 | 4.09 |
| DDT | 27.405 | 5.63 |
Description of key information
A reliable study for adsorption is available. Using the HPLC screening method the adsorption coefficient (Koc) was estimated to be less than 17.8 and the Log Koc was less than 1.25 indicating 2-propenoic acid, 2-fluoro, methyl ester will have a very high mobility in the environment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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