Registration Dossier
Registration Dossier
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EC number: 204-062-1 | CAS number: 115-07-1
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The registered substance is highly volatile which complicates environmental testing. Therefore, a modeling framework is needed to account for the bioavailability of the substance to perform read-across and data gap filling. The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms.
The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values for propene were 39.55 and 7.58 mg/kg soil dw for short-term (28-day LL50) and long-term effects (56-day NOELR), respectively.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 39.55 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 7.58 mg/kg soil dw
Additional information
Propene is a gas at standard temperature and pressure and is expected to partition primarily to air, therefore terrestrial toxicity tests may not be relevant. In addition, it is technically difficult to maintain terrestrial concentrations of gases for toxicity testing.
Measured data are not available for propene for this endpoint. Due to the practical difficulties associated with the ecotoxicity testing of gases (i.e. maintaining exposure concentrations) the use of QSAR toxicity estimates is an appropriate alternative. The ECOSAR model is a reliable and appropriate QSAR model to apply to propene as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis. The endpoint calculated here is therefore a reasonable estimate of its baseline toxicity. This was used as the key endpoint in the draft SIDS for propene (2003).
The TLM-EqP modeling has been validated as a suitable method for predicting effect values in sediment and soil organisms. The TLM-EqP predicted effect values for propene were 39.55 and 7.58 mg/kg soil dw for short-term (28-day LL50) and long-term effects (56-day NOELR), respectively.
A QSAR (ECOWIN v1 ECOSAR, Nabholz and Mayo-Bean 2009) has been used to give an indication of the toxicity of propene to the earthworm. The calculated 14-day LC50 is 77.3 mg/kg soil dw from ECOSAR.
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