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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
other: Gravimetric method
Principles of method if other than guideline:
Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Key result
Medium:
other: acetonitrile, methanol
Solubility:
> 1 000 g/L
Temp.:
33.4 °C
Remarks on result:
other: No other detail available
Key result
Medium:
other: acetone, ethanol and DMF
Solubility:
>= 200 - <= 1 000 mg/L
Temp.:
33.4 °C
Remarks on result:
other: No other detail available
Key result
Medium:
toluene
Solubility:
> 1 mg/L
Temp.:
33.4 °C
Remarks on result:
other: No other detail available
Conclusions:
The solubility determination of test substance in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetonitrile, methanol was determine to be greater than 1000 mg/l whereas the value in acetone, ethanol and DMF was determine to be in the range of 200 – 1000 mg/l and in Toluene it was determine to be less than 1mg/L respectively at 33.4 °C.
Executive summary:

The solubility determination of test substance in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetonitrile, methanol was determine to be greater than 1000 mg/l whereas the value in acetone, ethanol and DMF was determine to be in the range of 200 – 1000 mg/l and in Toluene it was determine to be less than 1mg/L respectively at 33.4 °C.

Description of key information

The solubility determination of test substance in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetonitrile, methanol was determine to be greater than 1000 mg/l whereas the value in acetone, ethanol and DMF was determine to be in the range of 200 – 1000 mg/l and in Toluene it was determine to be less than 1mg/L respectively at 33.4 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
1 000 000 mg/L

Additional information

The solubility determination of test substance in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetonitrile, methanol was determine to be greater than 1000 mg/l whereas the value in acetone, ethanol and DMF was determine to be in the range of 200 – 1000 mg/l and in Toluene it was determine to be less than 1mg/L respectively at 33.4 °C.

Solubility of test chemical in benzene is as follows:-

199868.16 mg/L (0.62 mol/kg) at temperature 25°C, 428749.44 mg/L (1.33 mol/kg) at temperature 30°C, 1038024.96 mg/L (3.22 mol/kg) at temperature 40°C, 1943879.04 mg/L (6.03 mol/kg) at temperature 50°C. In summary, test chemical is very soluble in benzene over a temperature range of 25 to 50 deg C.