Registration Dossier
Registration Dossier
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EC number: 203-439-8 | CAS number: 106-89-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
A comprehensive disposition and metabolism study of epichlorohydrin (ECH) revealed that the half-life of initial elimination of radioactivity in both urine and exhaled air was about 2 hr, indicating that ECH was rapidly absorbed and metabolized. The major metabolites in the urine were identified as N-acetyl-S-(3 -chloro-2 -hydroxypropyl)-L-cysteine and a-chlorohydrin, about 36 and 4% of the administered dose, respectively. Finding these metabolites is consistent with the initial metabolic reactions being conjugation of the epoxide with glutathione and hydration of the epoxide.
Urinary metabolites from orally dosed rats showed 9 peaks by ion-exclusion chromatography. Comparison of Epi-3-14c and Epi-1, 3-14c excretion data indicates that if any Epi carbon-to-carbon bond is broken the molecule is metabolized completely to CO2.
Nine radiolabeled components have been separated from the urine of rats exposed orally to 50 mg/kg 1,3-14C-epichlorohydrin using ion-exclusion liquid chromatography.
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