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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-cyclohexanediacetic acid monoamide
EC Number:
449-430-4
EC Name:
1,1-cyclohexanediacetic acid monoamide
Cas Number:
99189-60-3
Molecular formula:
C10H17NO3
IUPAC Name:
2-[1-(carbamoylmethyl)cyclohexyl]acetic acid

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
not specified
Limit test:
yes
Total exposure duration:
48 h

Test conditions

pH:
adjusted to 7.8

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility

Any other information on results incl. tables

No immobilized test organisms were observed during the test period.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The 48 hour NOEC and the 48 hour EC0 of 1,1-cyclohexanediacetic acid monoamide to Daphnia magna were determined to be at least 100mg/L. Concentration above 100mg/L were not tested, according to the EU Commission Directive. The 48-hour EC50 and the 48 hour EC100 were clearly higher than 100mg/L. These values could not be quantified due to the absence of toxicity of 1,1-cyclohexanediacetic acid monoamide at the test concentration of 100mg/L.