Registration Dossier
Registration Dossier
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EC number: 202-613-0 | CAS number: 97-86-9
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Compared to nBMA, i-BMA has a very similar ecotoxicological profile (fish acute, invertebrate acute, algae acute and chronic) and by virtue of having almost identical physicochemical properties and metabolism is predicted to be comparable to n-BMA in ecotoxicological QSARs for methacrylate esters. Here also the current PNEC is likely to provide a more conservative margin of safety and further testing is unlikely to provide a higher level of protection.
Key value for chemical safety assessment
Additional information
The CSA can be performed without a chronic fish study. With the available information the resulting PNEC is high enough so that the CSA could be concluded successfully. From the available acute data for this substance and the chronic data that is available, for all 3 trophic levels, for the close structural analogue (MMA) and the primary metabolite (MAA) there is no indication that fish are any more sensitive than aquatic invertebrates and algae to this substance (Staples et al., 2009). Therefore, performing the chronic fish study, a vertebrate study falling under the animal protection legislation of the EU (86/609/EEC), is unjustified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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