Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 212-485-8 | CAS number: 822-06-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given; publication meets generally accepted scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from 1,6-diisocyanatohexane in an anti-pill finish
- Author:
- Wilkinson SM et al.
- Year:
- 1 991
- Bibliographic source:
- Contact Derm. 25: 94-96
- Reference Type:
- publication
- Title:
- Occupational allergic contact dermatitis from 1,6 di-isocyanatohexane in a fabric finish
- Author:
- Cartwright PH et al.
- Year:
- 1 990
- Bibliographic source:
- Contact Dermatitis 23 (4): 252
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: Patch test with volunteers
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexamethylene diisocyanate
- EC Number:
- 212-485-8
- EC Name:
- Hexamethylene diisocyanate
- Cas Number:
- 822-06-0
- Molecular formula:
- C8H12N2O2
- IUPAC Name:
- 1,6-diisocyanatohexane
Constituent 1
Method
- Type of population:
- occupational
- Route of administration:
- dermal
Results and discussion
Any other information on results incl. tables
6/6 operatives that suffered from occupational contact dermatitis reacted strongly positive in a patch test with 0.1 % HDI solved in petrolatum, while all of the 20 control subjects were negative
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
