Registration Dossier
Registration Dossier
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EC number: 202-532-0 | CAS number: 96-76-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) 1.4 mg/L (OECD 204)
NOAEL (14 days) 0.30 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.4 mg/L
Additional information
Two studies were conducted in fish using 2,4-DTBP; a rainbow trout 96h study (Sewell I.G. (1991)) and a Golden ide (Scholz N. (1987)) 48h study. The LC50 from the rainbow trout was found to be greater than the highest value tested and is therefore not considered appropriate for setting the PNEC. The second study conducted using Golden ide is also not considered appropriate for setting the PNEC as the study was performed over 48h and not 96h, and the test species is not a standard species as defined in the OECD Guideline 203. It was therefore considered more appropriate to read across to the studies conducted using 2,6-DTBP. Four studies were conducted in fish. Two acute studies (rainbow trout and zebra fish) and two prolonged toxicity tests (14 days; rainbow trout and fathead minnows). From the 14 day studies conducted in fathead minnows and rainbow trout it was also possible to determine 96 h LC50 values thereby satisfying the requirements of an acute toxicity test. Due to a poor dose response relationship the results from the 14 day prolonged toxicity test with rainbow trout were considered to have lower reliability than the fathead minnow results.
The two rainbow trout 96h LC50 results were greater than the highest value tested. The 96 h LC50 fathead minnow result therefore represents the lowest and most accurate result for basing the PNEC.
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