Registration Dossier
Registration Dossier
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EC number: 231-151-2 | CAS number: 7440-42-8
Carcinogenicity
Administrative data
Description of key information
According to regulation (EC) 1907/2006, Art. 10 and 12 in conjunction with Annex X, Section 8.9.1 a carcinogenicity study is not required for the tonnage band of 100 -1000 tons per year.
Further, metallic boron is void of (i) any toxic effects in acute and 28 -day repeated dose toxicity studies up to limit doses, (ii) local irritating effects in skin and eye irritation tests and (iii) genetic toxicity in three different in vitro test systems. Based on the above mentioned information and the assumed inertness based on its practically negligible water solubility and bioaccessibility in artificial body fluids, it is not scientifically plausible to assume any carcinogenic potential for this substance.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Elemental boron is void of (i) any toxic effects in acute and 28 -day repeated dose toxicity studies up to limit doses, (ii) local irritating effects in skin and eye irritation tests and (iii) genetic toxicity in three different in vitro test systems. Based on the above mentioned information and the assumed inertness based on its practically negligible water solubility and bioaccessibility in artificial body fluids, it is not scientifically plausible to assume any carcinogenic potential for this substance. No hazard classification is required.
Additional information
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