Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-408-6 | CAS number: 6259-76-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Literature review
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients
- Author:
- Belsito D, Bickers D, Bruze M, Calow P, Greim H, Hanifin J, Rogers A, Saurat J, Sipes I & Tagami H
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology Volume 45, Issue 1, Supplement 1,2007, Pages S318-S361
- Report date:
- 2007
Materials and methods
- Type of sensitisation studied:
- skin
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Literature review
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexyl salicylate
- EC Number:
- 228-408-6
- EC Name:
- Hexyl salicylate
- Cas Number:
- 6259-76-3
- Molecular formula:
- C13H18O3
- IUPAC Name:
- hexyl salicylate
- Details on test material:
- - Name of test material (as cited in study report): Hexyl salicylate
- Analytical purity: One sample was 50% solution in DEP and the other was 100% pure
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A review of dermal sensitisation of Hexyl Salicylate was conducted. Cross sensitization reactions in humans who were induced with 30% hexyl salicylate and challenged with 15% benzyl salicylate (both substances dissolved in 3: 1 DEP:ethanol) have reportedly been observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
