Registration Dossier
Registration Dossier
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EC number: 235-476-0 | CAS number: 12239-87-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 952
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- Principles of method if other than guideline:
- No data given.
- GLP compliance:
- not specified
Test material
- Details on test material:
- No data given.
Constituent 1
Test animals
- Species:
- other: rabbit and guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- No data given.
- Frequency of treatment:
- No data given.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 40 mg/kg bw/day
- Remarks:
- approx. 40 mg/kg bw/day in rabbits for at least one month.
- Dose / conc.:
- 100 mg/kg bw/day
- Remarks:
- [probably] 100 mg/kg bw/day in guinea pigs.
- No. of animals per sex per dose:
- No data given.
- Control animals:
- not specified
- Details on study design:
- No data given.
Examinations
- Observations and examinations performed and frequency:
- No data given.
- Sacrifice and pathology:
- No data given.
- Other examinations:
- No data given.
Results and discussion
Results of examinations
- Details on results:
- No weight loss or effects on red blood cells were seen in rabbits. Doses applied in guinea pigs were similarly not overtly toxic.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
