Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-670-0 | CAS number: 683-18-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The following studies have been submitted to address the toxicity to microorganisms endpoint:
Stasinakis A et al (2001). Toxicity of Organotin Compounds to Activated Sludge. Ecotoxicology and Environmental Safety 49, 275-280.
Steinhaüser K et al (1985). Investigations on the Aquatic Toxicity of Organotin Compounds. Vom Wasser, 65: 203-214.
Stasinakis et al (2001) has been allocated a Klimisch score of 2; Steinhaüser et al (1985) has been allocated a Klimisch score of 4. Stasinakis et al (2001) has been determined to be the key study for this endpoint.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 11.5 mg/L
Additional information
Stasinakis A et al (2001) was allocated as the key study for this data requirement. The study was a short-term screening test conducted to evaluated the toxicity of organotins to activated sludge and the impact of sludge age on the toxicity of these compounds. The study was performed in line with good scientific principles with a good level of reporting as such the study was assigned a reliability score of 2 (reliable with restrictions) and considered adequate for assessment inhibition of respiration rate of activated sludge heterotrophic microorganisms was determined for dibutyltin dichloride (DBTC). The effect of various experimental parameters, such as sludge age, concentrations of suspended solids, and exposure time, on toxicity was investigated. An increase in sludge age or in the concentration of suspended solids reduces the observed inhibition. Longer exposure seems to increase the inhibition during the first hours of exposure, while later the inhibition remains constant. The IC50 was determined for DBT to be 11.5 mg/L (sludge age 10 days) and 35.6 mg/L (sludge age 20 days).
Two studies by Steinhaüser K et al (1985), were assigned reliability scores of 4 (not assignable). The studies were published within the same literature paper, but were performed using different species of bacteria. The firststudy using Photobacterium phosphoreum the reported the test material to have an LC50 value of 217µg/L. (Details of the toxic effects were not reported other than the effects concentration.). The second study used Pseudonomas putida, with which an EC10 value of 2500 µg/L was reported (Details of the toxic effects other than the effects of concentration for this species were also not reported.)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
