Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-168-8 | CAS number: 1761-71-3
Endpoint summary
Administrative data
Description of key information
Several case reports have been published suggesting an association between a scleroderma-like syndrome and occupational exposure to PACM (4,4'-methylenedicyclohexanamine) and other organic solvents.
Additional information
PACM has been suggested to be the cause of an occupationally-induced scleroderma syndrome in a Japanese epoxy resin polymerization plant, in the years prior to 1980 (Ohshima et al, 1986; Yamakage et al., 1980). Similar physical symptoms were later reported by Yamakage and Ishikawa (1982) among workers exposed to a variety of organic solvents. Other factors, such as infectious agents, nutritional deficits and genetic predisposition were not considered. More recent studies suggest that other components of epoxy resins, such as isocyantes, are contributors to dermal sensitisation and irritation effects. The epidemiologic data do not clearly support the hypothesis that 4,4'-methylenedicyclohexanamine causes a scleroderma-like syndrome in occupationally-exposed workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
