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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information

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Description of key information

The effects of 4-nitro-2-methoxyaniline on the activity of liver enzymes and on the formation of methemoglobin was determined.
Concern about Methemoglobine formation arose from the chemical structure as an aromatic amine. No changes in methemoglobin concetrations in blood of cats were detected.
4-nitro-2-methoxy aniline increased selectively the concentration of CYP1A2 in livers of rats.

Additional information