Registration Dossier
Registration Dossier
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EC number: 213-969-1 | CAS number: 1070-10-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable. The results (48-h LC50) of the main decomposition product 2-ethylhexanol and the analogue categy member (titanium tetra(octanolate), branched and linear) are used as a key value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 40 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than 2-ethylhexanol and hydrated titanium dioxide (half-life < 10 minutes, Brekelmans M.J.C. 2013). The organic decomposition product 2 -ethylhexanol is readily biodegradable and not persistent ( log Kow value 2.9 < 4). Therefore, the testing was considered unnecessary. The CSA indicates that toxicity of this substance is similar to the main degradation product 2-ethylhexanol based on the weight of evidence which uses the studies conducted for the analogue category member and the degradation product (2 -ethylhexanol).
Key studies (short-term toxicity to daphnia and algae) conducted for the analogue category member (titanium tetra(octanolate), branched and linear, CAS 68526 -83 -0) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.
This read-across substance is an analogue substance grouped together with the target substance into the category of highly water reactive titanates. It contains commercial solvent (alcohols C7 -9-iso, C8-rich, CAS no 68526 -83 -0). This solvent contains 93 % of isooctanol being also an analogue substance with 2 -ethylhexanol; an isomer of octyl alcohol.
The 48-h EC50 (immobilisation) to Daphnia magna measured by using OECD 202 in accordance with GLP was conducted for the analogue category member. As the test substance hydrolysed during testing, the test concentrations were measured based on the released octyl alcohol isomers. Test substance did not induce acute immobilization of D.magna at an average exposure concentration of 19 mg octyl alcohol isomers per litre. Based on this study results, the 48h-EC50 was 41 mg octyl alcohol isomers /l based on average measured exposure concentration (95% confidence interval between 37 and 49 mg/l).
In addition, a reliable 48-h EC50 (immobilisation) of 2-ethylhexanol to Daphnia magna is 39 mg/L. This study was conducted according EEC 84/449, C.2 ( i.e. similar to OECD test guideline 202) in accordance with GLP (Scholz 1991).
Based on the weight of evidence approach, the results of the analogue category member and the degradation products are very similar. Therefore, the key value of 40 mg/l for CSA is obtained as an average of these results.
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